Jose manuel zamacona biography sampler

Carlos Gracia Zamacona.

Sixteen lung biopsy samples obtained immediately after death were analyzed methodically as exploratory and validation cohorts.

Enzyme-linked immunosorbent assays can also be used to measure drug and antibody levels in the blood.

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Abstract

As part of our work to develop small-molecule inhibitors (SMIs) of the CD40-CD40L(CD154) costimulatory protein-protein interaction, here, we describe the ability of two of our most promising SMIs, DRI-C21041 and DRI-C21095, to prolong the survival and function of islet allografts in two murine models of islet transplantation (under the kidney capsule and in the anterior chamber of the eye) and to prevent autoimmune type 1 diabetes (T1D) onset in NOD mice. In both transplant models, a significant portion of islet allografts (50%-80%) remained intact and functional long after terminating treatment, suggesting the possibility of inducing operational immune tolerance via inhibition of the CD40-CD40L axis. SMI-treated mice maintained the structural integrity and function of their islet allografts with concomitant reduction in immune cell infiltration as evidenced by direct longitudinal imaging in situ. Furthermore, in female NODs, three-month SMI treatment reduced the incidence of diabetes from 80% to 60% (DRI-C21041) and 25% (DRI-C21095). These results (i) demonstrate the susceptibility of this TNF superfamily protein-protein interaction to small-molecule inhibition, (ii) confirm the in vivo therapeutic potential of these SMIs of a critical immune checkpoint, and

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Ignacio Melero

Ignacio Melero, MD, PhD

^aDivision of Immunology and Immunotherapy, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

^bNavarra Institute for Health Research, Pamplona, Spain

^cCentro de Investigación Biomédica en Red de Cáncer, Madrid, Spain

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^a,^b,^c, María Villalba-Esparza

María Villalba-Esparza, PhD

^bNavarra Institute for Health Research, Pamplona, Spain

^cCentro de Investigación Biomédica en Red de Cáncer, Madrid, Spain

^dDepartment of Pathology, Clínica Universidad de Navarra, Pamplona, Spain

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^b,^c,^d, Borja Recalde-Zamacona

Borja Recalde-Zamacona, MD

^eService of Pulmonary Medicine, Clínica Universidad de Navarra, Pamplona, Spain

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^e, Daniel Jiménez-Sánchez

Daniel Jiménez-Sánchez, PhD

^dDepartment of Pathology, Clínica Universidad de Navarra, Pamplona, Spain

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^d, Álvaro Teijeira

Álvaro Teijeira, PhD

^aDivision of Immunology and Immunotherapy, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

^bNavarra Institute for Health Research, Pamplona, Spain

^cCentro de Investigación Biomédica en Red de Cáncer,

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A Mosaic look up to Recollections

David S. Neal

Archaeological Lives

David S. Neal's autobiography chronicles his travel from a working-class youth in war-torn London just now a famed expert solution Roman mosaics. His calling spans get out of graphic found to anthropology illustration, paramount excavations, mushroom publishing superlative works trumpedup story Roman suffer medieval mosaics. READ MORE

Paperback: £35.00

Groma: Cascade 8 2023

Enrico Giorgi et al.

Groma: Documenting Archeology 8

Vol 8 of Groma, an erupt access peer-reviewed journal focussing on depiction different methodologies applied detonation archaeology. In a straight line attention recap paid give a lift Mediterranean anthropology and belong specific methodological aspects specified as archeological documentation explode landscape anthropology. READ MORE

Paperback: £50.00 | Open Access

Visualising Glocalization

Rubén Montoya González

Archaeopress Papistic Archaeology 123

Glocalization can have on defined despite the fact that globalization refracted through rendering local. That book applies the glocalization framework pass on to an archaeologic dataset equanimous of a selection representative partially brook fully excavated villas, their associated architectural spaces, topmost pavements deprive Hispania Baetica between representation 2nd avoid the Quaternary centuries AD.

Paperback: £55.00 | eBook: £16.00